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SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term)

Details for Product anti-SOCS1 Antibody No. ABIN782868, Supplier: Login to see New
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Synonyms socs1, zgc:91868, jab, cis1, ssi1, tip3, cish1, ssi-1, socs-1, SOCS1, LOC100228306, socs1b, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, Cish1, Cish7, Socs-1
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(60), (27), (13), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(153), (65), (54), (7), (7), (4), (2), (2), (1)
(137), (18), (10)
This SOCS1 antibody is un-conjugated
(7), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(142), (57), (35), (29), (11), (10), (9), (7), (4), (4), (2), (1)
Pubmed 1 reference available
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Quantity 20 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide from the C-Terminus of Human SOCS1 (NP_003736.1). Genename: SOCS1
Specificity Recognizes Suppressor Of Cytokine Signaling 1 (SOCS1) at C-term.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Canine (Dog) and Bovine.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name SOCS1 (SOCS1 Antibody Abstract)
Background SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
Gene ID 8651
NCBI Accession NP_003736
UniProt O15524
Research Area Chromatin and Nuclear Signaling, Signaling, Cytokines
Pathways JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline buffer, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 2)
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 3)
Background publications Starr, Willson, Viney et al.: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997 (PubMed).

Catalog No. ABIN782868
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