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NCF1 antibody (Neutrophil Cytosol Factor 1) (C-Term)

Details for Product anti-NCF1 Antibody No. ABIN782871, Supplier: Log in to see
Antigen
  • NCF1A
  • NOXO2
  • SH3PXD1A
  • p47phox
  • Ncf-1
  • p47
Alternatives
anti-Human NCF1 antibody for Western Blotting
Epitope
C-Term
54
22
15
15
13
10
9
5
5
5
3
3
2
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
168
66
64
12
9
7
6
6
5
4
2
1
Host
Goat
155
26
2
Clonality
Polyclonal
Conjugate
This NCF1 antibody is un-conjugated
5
5
5
3
3
3
3
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
140
88
84
24
23
21
10
4
4
2
1
Supplier
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Immunogen Peptide from the C Terminus of the protein according to NP_000256.3. Genename: NCF1
Sequence C-SESTKRKLAS AV
Specificity This antibody detects NCF-1 at C-term.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Rabbit, Pig, Cow.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name NCF1 (NCF1 Antibody Abstract)
Background NCF1, along with NCF2 and a membrane bound cytochrome b558, is required for activation of the latent NADPH oxidase necessary for superoxide production. Defects in NCF1 are the cause of autosomal cytochrome-b-positive chronic granulomatous disease type 1 (CGD).Synonyms: 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-1, NCF-47K, NOXO2, Neutrophil NADPH oxidase factor 1, Neutrophil cytosol factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, SH3PXD1A, p47-phox
Gene ID 653361
NCBI Accession NP_000256
UniProt P14598
Research Area Cancer, Metabolism
Pathways PI3K-Akt Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-NCF1 antibody (Neutrophil Cytosol Factor 1) (C-Term) (ABIN782871) anti-Neutrophil Cytosol Factor 1 (NCF1) (C-Term) antibody
Background publications Underhill, Rossnagle, Lowell et al.: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).