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SMAD2 antibody (SMAD, Mothers Against DPP Homolog 2) (Internal Region)

Details for Product anti-SMAD2 Antibody No. ABIN782878, Supplier: Log in to see
Antigen
  • 7120426M23Rik
  • fj43c06
  • hmad-2
  • hMAD-2
  • hsmad2
  • hSMAD2
  • JV18
  • jv18
  • jv18-1
  • JV18-1
  • Madh2
  • MADH2
  • madh2
  • madr2
  • MADR2
  • Madr2
  • mMad2
  • Smad-2
  • smad-2
  • wu:fj43c06
  • Xmad2
  • XSmad2
Alternatives
anti-Human SMAD2 antibody for Western Blotting
Epitope
Internal Region
52
42
30
26
22
17
15
13
12
11
9
7
6
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human
401
179
161
20
16
8
8
8
8
8
6
5
2
2
2
1
1
1
1
1
1
1
1
Host
Goat
337
53
21
Clonality
Polyclonal
Conjugate
This SMAD2 antibody is un-conjugated
14
12
10
8
8
8
4
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
332
187
82
82
47
37
27
25
19
12
5
5
5
3
3
Supplier
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Immunogen Peptide from the internal region of the protein sequence according to NP_005892.1. Genename: SMAD2
Sequence EIWGLSTPNT IDC
Specificity This antibody detects SMAD2 (Internal).
Cross-Reactivity (Details) Species reactivity (expected):Cow.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Alternative Name SMAD2 (SMAD2 Antibody Abstract)
Background SMAD2 (Mothers against decapentaplegic homolog 2) belongs to the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated Smad2 is then able to form a complex with Smad4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.Synonyms: JV18-1, MAD homolog 2, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, SMAD 2, SMAD family member 2, SMAD-2
Gene ID 4087
NCBI Accession NP_005892
UniProt Q15796
Research Area Signaling, Transcription Factors
Pathways Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preserative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-SMAD2 antibody (SMAD, Mothers Against DPP Homolog 2) (Internal Region) (ABIN782878) anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Internal Region) antibody
Background publications Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma." in: Cell, Vol. 86, Issue 4, pp. 543-52, 1996 (PubMed).