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FOXP3 antibody (Forkhead Box P3) (C-Term)

Details for Product anti-FOXP3 Antibody No. ABIN782895, Supplier: Log in to see
Antigen
  • AIID
  • DIETER
  • foxp3
  • FOXP3
  • IPEX
  • JM2
  • PIDX
  • RGD1562112
  • scurfin
  • sf
  • XPID
Epitope
C-Term
104
52
18
18
14
13
13
13
11
7
6
6
6
6
6
5
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Pig (Porcine)
436
291
63
44
24
23
20
16
12
9
8
4
2
2
1
1
Host
Goat
247
200
65
33
Clonality
Polyclonal
Conjugate
This FOXP3 antibody is un-conjugated
42
33
24
22
22
19
16
10
9
9
9
9
6
6
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
Application
Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
310
234
152
108
69
65
55
49
43
38
17
5
4
3
2
2
2
1
Supplier
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Immunogen Peptide from C-Terminus of the protein sequence according to NP_054728.2, NP_001107849.1. Genename: FOXP3
Sequence SQRPSRCSNP TPGP
Specificity This antibody is expected to recognize both reported isoforms (NP_054728.2 and NP_001107849.1).
Cross-Reactivity (Details) Species reactivity (expected):Canine (Dog) and Pig.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name FOXP3 (FOXP3 Antibody Abstract)
Background FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
Gene ID 50943
NCBI Accession NP_054728
UniProt Q9BZS1
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-FOXP3 antibody (Forkhead Box P3) (C-Term) (ABIN782895) anti-Forkhead Box P3 (FOXP3) (C-Term) antibody
 image for anti-FOXP3 antibody (Forkhead Box P3) (C-Term) (ABIN782895) anti-Forkhead Box P3 (FOXP3) (C-Term) antibody (Image 2)
Background publications Stahl, Fauti, Ullrich, Bopp, Kubach, Rust, Labhart, Alexiadis, Becker, Hafner, Weith, Lenter, Jonuleit, Schmitt, Mennerich: "miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression." in: PLoS ONE, Vol. 4, Issue 9, pp. e7158, 2009 (PubMed).

Banham, Brown, Lyne, Schulze, Hallermann: "Is FOXP3 expressed in cutaneous T-cell lymphomas?" in: European journal of haematology, Vol. 80, Issue 1, pp. 90-1, 2008 (PubMed).

Mansour, Homs, Desvaux, Badoual, Dahan, Matignon, Audard, Lang, Grimbert: "Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change." in: Journal of the American Society of Nephrology : JASN, Vol. 19, Issue 12, pp. 2277-81, 2008 (PubMed).

Baumforth, Birgersdotter, Reynolds, Wei, Kapatai, Flavell, Kalk, Piper, Lee, Machado, Hadley, Sundblad, Sjoberg, Bjorkholm, Porwit, Yap, Teo, Grundy, Young, Ernberg, Woodman, Murray: "Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells." in: The American journal of pathology, Vol. 173, Issue 1, pp. 195-204, 2008 (PubMed).

Radulovic, Jacobson, Durham, Nouri-Aria: "Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 6, pp. 1467-72, 1472.e1, 2008 (PubMed).

Chaumont, Wipff: "Ion aggregation in concentrated aqueous and methanol solutions of polyoxometallates Keggin anions: the effect of counterions investigated by molecular dynamics simulations." in: Physical chemistry chemical physics : PCCP, Vol. 10, Issue 46, pp. 6940-53, 2008 (PubMed).

Ward, Hall, Cairns, Leggat, Urbaniak, Vickers, Barker: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, 2008 (PubMed).

Nakamura, Shima, Saeki, Hidaka, Nakashima, Takikawa, Saito: "Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer." in: Cancer science, Vol. 98, Issue 6, pp. 874-81, 2007 (PubMed).

Soler, Chapman, Poisson, Wang, Cote-Sierra, Ryan, McDonald, Badola, Fedyk, Coyle, Hodge, Kolbeck: "CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 10, pp. 6940-51, 2006 (PubMed).

Kitamura, Torigoe, Honma, Sato, Asanuma, Hirohashi, Sato, Tsukamoto: "Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus calmette-guerin immunotherapy for bladder cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 15, pp. 4641-4, 2006 (PubMed).

Appay, Jandus, Voelter, Reynard, Coupland, Rimoldi, Lienard, Guillaume, Krieg, Cerottini, Romero, Leyvraz, Rufer, Speiser: "New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 3, pp. 1670-8, 2006 (PubMed).

Epple, Loddenkemper, Kunkel, Tröger, Maul, Moos, Berg, Ullrich, Schulzke, Stein, Duchmann, Zeitz, Schneider: "Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART." in: Blood, Vol. 108, Issue 9, pp. 3072-8, 2006 (PubMed).

Michaëlsson, Mold, McCune, Nixon: "Regulation of T cell responses in the developing human fetus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5741-8, 2006 (PubMed).