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A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody

Details for Product No. ABIN782908
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Antigen
Synonyms adam8, reprolysin, si:zc217g15.7, zgc:64059, ADAM8, CD156, CD156a, E430039A18Rik, MS2, Adam8
Epitope
C-Term
(3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(9), (1)
Host
Goat
(6), (4)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(10), (5), (3), (2), (2)
Pubmed 1 reference available
Quantity 20 µg
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Catalog No. ABIN782908
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Immunogen Peptide from C Terminus of the protein sequence according to NP_001100.3, NP_001157962.1. Genename: ADAM8
Sequence C-QRKQGAGAPTAP
Specificity This antibody is expected to recognise isoform 1 and 3 (NP_001100.3 and NP_001157962.1). Species Reactivity: Tested: Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name CD156a / ADAM8
Background Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.
Alternate names: Cell surface antigen MS2, Disintegrin and metalloproteinase domain-containing protein 8, MS2
Gene ID 101
NCBI Accession NP_001100.3
UniProt P78325
Research Area Proteases, Extracellular Matrix
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 0.02% Sodium Azide 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody anti-A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody
Background publications Yoshiyama, Higuchi, Kataoka et al.: "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location." in: Genomics, Vol. 41, Issue 1, pp. 56-62, 1997 (PubMed).

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