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FOXA1 antibody (Forkhead Box A1) (C-Term)

Details for Product anti-FOXA1 Antibody No. ABIN782926, Supplier: Log in to see
Antigen
  • Ci-fkh
  • fkd7
  • fkh
  • fkh1
  • fkh2
  • forkhead-7
  • Foxa1
  • foxa1
  • FOXA1
  • foxa3
  • FoxA4a
  • HNF-3a
  • Hnf-3a
  • HNF3-alpha
  • HNF3A
  • Hnf3a
  • hnf3a
  • HNF3alpha
  • pintallavis
  • Tcf-3a
  • TCF3A
  • tcf3a
  • Tcf3a
  • tFoxA1
  • XFD-1
  • xfkh1
  • xfkh2
  • xkfh-1
Epitope
C-Term
32
19
16
16
14
13
9
7
6
5
4
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
195
33
30
6
6
4
3
2
1
1
1
Host
Goat
102
74
19
Clonality
Polyclonal
Conjugate
This FOXA1 antibody is un-conjugated
6
6
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
163
92
82
77
72
50
47
11
9
8
5
2
1
1
1
Supplier
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Immunogen Peptide from C-Terminus of the protein sequence according to NP_004487.2 Genename: FOXA1
Sequence C-GVYSRPVLNT S
Specificity This antibody detects FOXA1.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Pig, Cow.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name FOXA1 / TCF3A (FOXA1 Antibody Abstract)
Background FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.Synonyms: Forkhead box protein A1, HNF-3-alpha, HNF-3A, HNF3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, Transcription factor 3A
Molecular Weight 49.1 kDa (NP_004487.2)
Gene ID 3169
NCBI Accession NP_004487
UniProt P55317
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
Supplier Images
 image for anti-FOXA1 antibody (Forkhead Box A1) (C-Term) (ABIN782926) anti-Forkhead Box A1 (FOXA1) (C-Term) antibody
 image for anti-FOXA1 antibody (Forkhead Box A1) (C-Term) (ABIN782926) anti-Forkhead Box A1 (FOXA1) (C-Term) antibody (Image 2)
Background publications McMullin, Dobi, Mutton, Orosz, Maheshwari, Shashikant, Bieberich: "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 1, pp. 98-103, 2010

Taube, Allton, Duncan, Shen, Barton: "Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16135-44, 2010

Eeckhoute, Lupien, Meyer, Verzi, Shivdasani, Liu, Brown: "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers." in: Genome research, Vol. 19, Issue 3, pp. 372-80, 2009

Hua, Kittler, White: "Genomic antagonism between retinoic acid and estrogen signaling in breast cancer." in: Cell, Vol. 137, Issue 7, pp. 1259-71, 2009

Lupien, Eeckhoute, Meyer, Wang, Zhang, Li, Carroll, Liu, Brown: "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription." in: Cell, Vol. 132, Issue 6, pp. 958-70, 2008

Eeckhoute, Carroll, Geistlinger, Torres-Arzayus, Brown: "A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer." in: Genes & development, Vol. 20, Issue 18, pp. 2513-26, 2006

Nguyen, Cho, Stratton, Barton: "Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2147-57, 2005

Carroll, Liu, Brodsky, Li, Meyer, Szary, Eeckhoute, Shao, Hestermann, Geistlinger, Fox, Silver, Brown: "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1." in: Cell, Vol. 122, Issue 1, pp. 33-43, 2005