Forkhead Box A1 (FOXA1) (C-Term) antibody

Details for Product No. ABIN782926
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Antigen
Synonyms
FoxA4a, XFD-1, fkh1, foxa1, pintallavis, xfkh1, xkfh-1, HNF3-alpha, HNF3alpha, Hnf3a, fkh2, tFoxA1, tcf3a, xfkh2, fkh, FOXA1, Ci-fkh, foxa3, Foxa1, fkd7, forkhead-7, hnf3a, HNF3A, TCF3A, HNF-3a, Hnf-3 ... show more
FoxA4a, XFD-1, fkh1, foxa1, pintallavis, xfkh1, xkfh-1, HNF3-alpha, HNF3alpha, Hnf3a, fkh2, tFoxA1, tcf3a, xfkh2, fkh, FOXA1, Ci-fkh, foxa3, Foxa1, fkd7, forkhead-7, hnf3a, HNF3A, TCF3A, HNF-3a, Hnf-3a, Tcf-3a, Tcf3a show less
Epitope
C-Term
(24), (11), (8), (7), (6), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(92), (12), (9), (4), (3), (3), (2), (2), (1)
Host
Goat
(49), (35), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(74), (43), (40), (18), (12), (8), (7), (4), (4), (3), (2), (1)
Pubmed 8 references available
Quantity 20 μg
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Catalog No. ABIN782926
176.00 $
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Immunogen Peptide from C-Terminus of the protein sequence according to NP_004487.2 Genename: FOXA1
Sequence C-GVYSRPVLNT S
Specificity This antibody detects FOXA1.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Pig, Cow.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name FOXA1 / TCF3A
Background FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.Synonyms: Forkhead box protein A1, HNF-3-alpha, HNF-3A, HNF3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, Transcription factor 3A
Molecular Weight 49.1 kDa (NP_004487.2)
Gene ID 3169
NCBI Accession NP_004487
UniProt P55317
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
Supplier Images
anti-Forkhead Box A1 (FOXA1) (C-Term) antibody anti-Forkhead Box A1 (FOXA1) (C-Term) antibody
anti-Forkhead Box A1 (FOXA1) (C-Term) antibody (2) anti-Forkhead Box A1 (FOXA1) (C-Term) antibody (Image 2)
Background publications Nguyen, Cho, Stratton et al.: "Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2147-57, 2005 (PubMed).

Carroll, Liu, Brodsky et al.: "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1." in: Cell, Vol. 122, Issue 1, pp. 33-43, 2005 (PubMed).

Eeckhoute, Carroll, Geistlinger et al.: "A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer." in: Genes & development, Vol. 20, Issue 18, pp. 2513-26, 2006 (PubMed).

Lupien, Eeckhoute, Meyer et al.: "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription." in: Cell, Vol. 132, Issue 6, pp. 958-70, 2008 (PubMed).

Eeckhoute, Lupien, Meyer et al.: "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers." in: Genome research, Vol. 19, Issue 3, pp. 372-80, 2009 (PubMed).

Hua, Kittler, White: "Genomic antagonism between retinoic acid and estrogen signaling in breast cancer." in: Cell, Vol. 137, Issue 7, pp. 1259-71, 2009 (PubMed).

McMullin, Dobi, Mutton et al.: "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 1, pp. 98-103, 2010 (PubMed).

Taube, Allton, Duncan et al.: "Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16135-44, 2010 (PubMed).

Validation Images
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