DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody

Details for Product No. ABIN783010
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Antigen
Synonyms
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, mta, cb983, dmnt1, cb1075, fb05h01, wu:fb05h01, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSF ... show more
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, mta, cb983, dmnt1, cb1075, fb05h01, wu:fb05h01, DDM2, DECREASED DNA METHYLATION 2, DMT01, DMT1, DNA METHYLTRANSFERASE, DNA METHYLTRANSFERASE 01, DNA METHYLTRANSFERASE 1, MET2, METHYLTRANSFERASE 2, METHYLTRANSFERASE I, METI, methyltransferase 1, Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, m.MmuI show less
Epitope
Internal Region
(16), (13), (12), (12), (8), (6), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(152), (63), (58), (51), (41), (32), (24), (6), (2), (1), (1), (1)
Host
Goat
(129), (17), (8), (8), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(98), (50), (50), (38), (23), (14), (10), (10), (9), (7), (4), (3), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN783010
Quantity 20 µg
Price
176.00 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence from the internal egion of the protein sequence Genename: DNMT1
Sequence C-RFESPPKTQPTEDN
Specificity This antibody recognizes DNMT1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine, Bovine, Porcine.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name DNMT1
Background Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt 1, Dnmt 2 and Dnmt 3. Dnmt 1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt 2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt 3a and Dnmt 3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F 1, and HDAC 1. Dnmt 1 also cooperates with Rb to repress transcription from promoters containing E2F binding sites suggesting a link between DNA methylation, histone deacetylase and sequence specific DNA binding activity, as well as a growth regulatory pathway that is disrupted in nearly all cancer cells.
Alternate names: AIM, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase HsaI, HsaI, MCMT
Molecular Weight 183kDa (NP_001370.1).
Gene ID 1786
NCBI Accession NP_001124295
UniProt P26358
Research Area DNA/RNA
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody (2) anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody (Image 2)
Background publications Dion, Lin, Hubert et al.: "Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline." in: Human molecular genetics, Vol. 17, Issue 9, pp. 1306-17, 2008 (PubMed).

Hosts (129), (17), (8), (8), (2)
Reactivities (152), (63), (58), (51), (41), (32), (24), (6), (2), (1), (1), (1)
Applications (98), (50), (50), (38), (23), (14), (10), (10), (9), (7), (4), (3), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (16), (13), (12), (12), (8), (6), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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