Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 29-33) antibody

Details for Product No. ABIN783310
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Antigen
Synonyms
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Dric ... show more
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice, A830040C14Rik, AC-3, Apopain, CPP32, Lice, Yama, mldy, CPP32B, SCA-1, xcpp32 show less
Epitope
AA 29-33
(28), (22), (21), (15), (14), (12), (8), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(300), (118), (94), (19), (18), (18), (6), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(275), (52), (7), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (6), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(263), (118), (100), (91), (54), (31), (19), (19), (19), (14), (10), (4), (2), (2), (2)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN783310
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Immunogen Peptide sequence around aa.29~33 derived from Caspase 3
Sequence S-G-I-S-L
Specificity This antibody detects endogenous level of total Caspase 3 protein. Species Reactivity: Tested: Human
Purification Affinity-chromatography using epitope-specific peptide
Alternative Name Caspase-3
Background Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Alternate names: Apopain, CASP-3, CASP3, CPP-32, CPP32, Cysteine protease CPP32, SCA-1, SCA1, SREBP cleavage activity 1, Yama protein
Molecular Weight 35/19/17 kDa
Gene ID 836
NCBI Accession NP_004337
UniProt P42574
Research Area Apoptosis/Necrosis, Autophagy
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Nicholson, Ali, Thornberry et al.: "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis." in: Nature, Vol. 376, Issue 6535, pp. 37-43, 1995 (PubMed).

Gervais, Xu, Robertson et al.: "Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation." in: Cell, Vol. 97, Issue 3, pp. 395-406, 1999 (PubMed).

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