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Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (AA 29-33)

Details for Product anti-CASP3 Antibody No. ABIN783310, Supplier: Log in to see
Antigen
  • CC3
  • CG14902
  • Cas3
  • Casp 3
  • Casp3
  • Caspase-3
  • DECAY
  • Decay
  • Dmel\\CG14902
  • Drosophila executioner caspase related to Apopain/Yama
  • caspase 3
  • caspase-3
  • CG7788
  • DRICE
  • Dmel\\CG7788
  • DrICE
  • DrIce
  • Drice
  • ICE
  • crice
  • drICE
  • drIce
  • drice
  • ice
  • A830040C14Rik
  • AC-3
  • Apopain
  • CPP32
  • Lice
  • Yama
  • mldy
  • CPP32B
  • SCA-1
  • xcpp32
Alternatives
anti-Human Caspase 3 antibody for Western Blotting
Epitope
AA 29-33
37
31
30
30
19
19
18
17
14
13
13
12
12
10
9
8
7
6
6
6
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
450
189
137
27
17
14
13
13
12
9
6
5
5
4
3
2
1
Host
Rabbit
440
66
16
3
2
Clonality
Polyclonal
Conjugate
This Caspase 3 antibody is un-conjugated
24
21
17
10
10
9
4
3
2
2
2
2
2
2
2
1
1
Application
Western Blotting (WB)
365
193
160
87
63
58
37
25
23
21
13
10
7
3
2
2
2
2
2
2
1
1
1
1
1
Supplier
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Immunogen Peptide sequence around aa.29~33 derived from Caspase 3
Sequence S-G-I-S-L
Specificity This antibody detects endogenous level of total Caspase 3 protein.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity-chromatography using epitope-specific peptide
Alternative Name Caspase-3 (CASP3 Antibody Abstract)
Background Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.Synonyms: Apopain, CASP-3, CASP3, CPP-32, CPP32, Cysteine protease CPP32, SCA-1, SCA1, SREBP cleavage activity 1, Yama protein
Molecular Weight 35/19/17 kDa
Gene ID 836
NCBI Accession NP_004337
UniProt P42574
Research Area Apoptosis/Necrosis, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (AA 29-33) (ABIN783310) Western blot analysis of extracts from 293, Hela and MDA cells using Caspase 3.
Background publications Gervais, Xu, Robertson et al.: "Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation." in: Cell, Vol. 97, Issue 3, pp. 395-406, 1999 (PubMed).

Nicholson, Ali, Thornberry et al.: "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis." in: Nature, Vol. 376, Issue 6535, pp. 37-43, 1995 (PubMed).