LRRTM2 antibody (C-Term)

Catalog No. ABIN783381

Product Details anti-LRRTM2 Antibody

Target: LRRTM2 (Leucine Rich Repeat Transmembrane Neuronal 2 (LRRTM2))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects LRRTM2 at C-term. LRRTM2 antibody is predicted to not cross-react with other LRRTM family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the carboxy terminus of human LRRTM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for LRRTM2

Target: LRRTM2 (Leucine Rich Repeat Transmembrane Neuronal 2 (LRRTM2))

Alternative Name: LRRTM2 (LRRTM2 Products)

Synonyms: sc:d0320 antibody, AI851755 antibody, BB129880 antibody, C630011A14Rik antibody, mKIAA0416 antibody, leucine rich repeat transmembrane neuronal 2 antibody, LRRTM2 antibody, lrrtm2 antibody, Lrrtm2 antibody

Background: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.Synonyms: KIAA0416, LRRN2, Leucine-rich repeat neuronal 2 protein, Leucine-rich repeat transmembrane neuronal protein 2

Gene ID: 26045

NCBI Accession: NP_056379

UniProt: O43300

Pathways: Synaptic Membrane