RABGEF1 antibody (Center)

Catalog No. ABIN783421

Product Details anti-RABGEF1 Antibody

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RABGEF1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects RABGEF1 at Center. At least four isoforms of RABEX5 are known to exist, this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center terminus of human RABEX5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for RABGEF1

Target: RABGEF1 (RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1))

Alternative Name: RABGEF1 (RABGEF1 Products)

Background: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.Synonyms: RABEX5, RAP1, Rab5 GDP/GTP exchange factor, Rabaptin-5-associated exchange factor for Rab5, Rabex-5

Gene ID: 27342

NCBI Accession: NP_055319

UniProt: Q9UJ41

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process