This antibody detects TM4SF1 at N-term. At least three isoforms of TM4SF1 are known to exist, this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
18 amino acid peptide near the amino terminus of human TM4SF1
MGC85546 antibody, h-l6 antibody, m3s1 antibody, taal6 antibody, H-L6 antibody, L6 antibody, M3S1 antibody, TAAL6 antibody, MM3 antibody, M3s1 antibody, transmembrane 4 L six family member 1 antibody, transmembrane 4 L six family member 1 S homeolog antibody, transmembrane 4 superfamily member 1 antibody, TM4SF1 antibody, tm4sf1.S antibody, tm4sf1 antibody, Tm4sf1 antibody
Background
TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.Synonyms: M3S1, Membrane component surface marker 1, TAAL6, Transmembrane 4 L6 family member 1, Tumor-associated antigen L6