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ATP2C1 antibody (ATPase, Ca++ Transporting, Type 2C, Member 1) (C-Term)

Details for Product anti-ATP2C1 Antibody No. ABIN783438, Supplier: Log in to see
Antigen
  • 1700121J11Rik
  • ATP2C1
  • ATP2C1A
  • AW061228
  • BCPM
  • D930003G21Rik
  • HHD
  • hSPCA1
  • pmr1
  • PMR1
  • si:dkey-11p23.6
  • SPCA
  • Spca1
  • SPCA1
Epitope
C-Term
26
15
5
5
3
2
2
1
1
Reactivity
Human, Mouse (Murine)
85
29
23
12
7
2
1
1
1
1
Host
Rabbit
64
21
Clonality
Polyclonal
Conjugate
This ATP2C1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
68
41
22
13
10
6
3
2
2
2
1
Supplier
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Immunogen 19 amino acid peptide near the carboxy terminus of human ATP2C1
Specificity This antibody detects ATP2C1 (C-term). At least four isoforms of ATP2C1 are known to exist, this antibody will recognize only the three longest isoforms. ATP2C1 antibody will not cross-react with ATP2C2.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ATP2C1 (ATP2C1 Antibody Abstract)
Background ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.Synonyms: ATP-dependent Calcium pump PMR1, ATPase 2C1, Calcium-transporting ATPase type 2C member 1, HUSSY-28, KIAA1347, PMR1L
Gene ID 27032
NCBI Accession NP_001001485
UniProt P98194
Research Area Signaling, Metabolism, Enzymes
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ATP2C1 antibody (ATPase, Ca++ Transporting, Type 2C, Member 1) (C-Term) (ABIN783438) Western blot analysis of ATP2C1 in mouse brain tissue lysate with ATP2C1 antibody at ...
Background publications Grice, Vetter, Faddy, Kenny, Roberts-Thomson, Monteith: "Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231." in: The Journal of biological chemistry, Vol. 285, Issue 48, pp. 37458-66, 2010

Dode, Andersen, Vanoevelen, Raeymaekers, Missiaen, Vilsen, Wuytack: "Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3182-9, 2006

Hu, Bonifas, Beech, Bench, Shigihara, Ogawa, Ikeda, Mauro, Epstein: "Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease." in: Nature genetics, Vol. 24, Issue 1, pp. 61-5, 2000