Transportin 3 antibody (N-Term)

Catalog No. ABIN783562

Product Details anti-Transportin 3 Antibody

Target: Transportin 3 (TNPO3)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transportin 3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Transportin-3 (TNPO3) at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the amino terminus of human TNPO3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for Transportin 3

Target: Transportin 3 (TNPO3)

Alternative Name: Transportin-3 (TNPO3) (TNPO3 Products)

Synonyms: zgc:55409 antibody, tnpo3 antibody, MGC82948 antibody, TNPO3 antibody, DKFZp459J2330 antibody, IPO12 antibody, MTR10A antibody, TRN-SR antibody, TRN-SR2 antibody, TRNSR antibody, 5730544L10Rik antibody, C430013M08Rik antibody, C81142 antibody, D6Ertd313e antibody, Trn-SR antibody, mKIAA4133 antibody, transportin 3 antibody, transportin 3 S homeolog antibody, transportin-SR antibody, tnpo3 antibody, TNPO3 antibody, tnpo3.S antibody, Bm1_43850 antibody, LOAG_04608 antibody, Tnpo3 antibody

Background: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.Synonyms: IPO12, Imp12, Importin-12, TRN-SR, Transportin-SR

Gene ID: 23534

NCBI Accession: NP_001177957

UniProt: Q9Y5L0

Pathways: Protein targeting to Nucleus