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VPS53 antibody (Center)

VPS53 Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783566
  • Target See all VPS53 Antibodies
    VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))
    Binding Specificity
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 21
    • 9
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 19
    • 2
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VPS53 antibody is un-conjugated
    Application
    • 14
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects VPS53 at Center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide from near the center of human VPS53
    Top Product
    Discover our top product VPS53 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))
    Alternative Name
    VPS53 (VPS53 Products)
    Synonyms
    wu:fb77d11 antibody, zgc:103741 antibody, DKFZp469N152 antibody, 2010002A08Rik antibody, 2310040I21Rik antibody, 3100002B05Rik antibody, Hccs1 antibody, HCCS1 antibody, hVps53L antibody, pp13624 antibody, RGD1311391 antibody, VPS53, GARP complex subunit antibody, vacuolar protein sorting 53 homolog (S. cerevisiae) antibody, vacuolar protein sorting 53 antibody, VPS53 GARP complex subunit antibody, VPS53 antibody, vps53 antibody, PAAG_00802 antibody, MCYG_06020 antibody, VDBG_07188 antibody, MGYG_05943 antibody, Vps53 antibody
    Background
    The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.Synonyms: PP13624, Vacuolar protein sorting-associated protein 53 homolog
    Gene ID
    55275
    NCBI Accession
    NP_001121631
    UniProt
    Q5VIR6
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