ANAPC11 antibody (Center)

Catalog No. ABIN783600

Product Details anti-ANAPC11 Antibody

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC11 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human APC11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for ANAPC11

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Alternative Name: APC11 / ANAPC11 (ANAPC11 Products)

Synonyms: APC11 antibody, Apc11p antibody, anapc11 antibody, RGD1561880 antibody, F10A16.17 antibody, F10A16_17 antibody, anaphase-promoting complex/cyclosome 11 antibody, DDBDRAFT_0187183 antibody, DDBDRAFT_0231277 antibody, DDB_0187183 antibody, DDB_0231277 antibody, 1110011I19Rik antibody, R75218 antibody, zgc:153671 antibody, si:dkey-237i9.4 antibody, anaphase promoting complex subunit 11 antibody, anaphase promoting complex subunit 11 L homeolog antibody, anaphase-promoting complex/cyclosome 11 antibody, anaphase-promoting complex subunit Apc11 antibody, ubiquitin-protein ligase Anaphase Promoting Complex antibody, hypothetical protein antibody, predicted protein antibody, anaphase-promoting complex subunit 11 antibody, APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody, ANAPC11 antibody, anapc11.L antibody, anapc11 antibody, Anapc11 antibody, APC11 antibody, apc11 antibody, CAALFM_CR10610CA antibody, LOC9320604 antibody, LOC692923 antibody

Background: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.Synonyms: Anaphase-promoting complex subunit 11, Cyclosome subunit 11, HSPC214, Hepatocellular carcinoma-associated RING finger protein

Gene ID: 51529

NCBI Accession: NP_001002244

UniProt: Q9NYG5