Retinoblastoma Binding Protein 8 antibody (Center)

Catalog No. ABIN783608

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the center of human RBBP8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8 (RBBP8 Products)

Synonyms: COM1 antibody, CTIP antibody, JWDS antibody, RIM antibody, SAE2 antibody, SCKL2 antibody, 9930104E21Rik antibody, CtIP antibody, RBBP-8 antibody, RGD1308872 antibody, RBBP8 antibody, DKFZp469K0714 antibody, RB binding protein 8, endonuclease antibody, retinoblastoma binding protein 8, endonuclease antibody, retinoblastoma binding protein 8 L homeolog antibody, retinoblastoma binding protein 8 antibody, RBBP8 antibody, Rbbp8 antibody, rbbp8.L antibody, rbbp8 antibody

Background: RBBP8, also known as CtBP (carboxy-terminal binding protein) interacting protein (CTIP), was characterized for its role in transcription as a cofactor for the transcriptional repressor CtBP, and also as a binding partner for other proteins including the cell cycle regulators retinoblastoma protein (Rb) and breast cancer 1 (BRCA1). It is ubiquitously expressed and localizes to the nucleus. RBBP8 is thought to modulate the functions in cell proliferation, transcriptional regulation and DNA repair. RBBP8 also plays a central role in the cell cycle checkpoint response to DNA double-stranded breaks (DSBs), with new evidence demonstrating that it controls the choice of DSB repair pathway.Synonyms: CTIP, CtBP-interacting protein, RBBP-8, Retinoblastoma-binding protein 8, Retinoblastoma-interacting protein and myosin-like

Gene ID: 5932

NCBI Accession: NP_002885

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair