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Tectonic Family Member 2 (TCTN2) (C-Term) antibody

Details for Product No. ABIN783638, Supplier: Login to see
Antigen
  • fb44f11
  • wu:fb44f11
  • tect2
  • C12orf38
  • MKS8
  • TECT2
  • 4432405B04Rik
  • Tect2
Epitope
C-Term
9
2
Reactivity
Human, Mouse (Murine)
35
24
21
Host
Rabbit
37
1
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
22
12
11
7
4
3
2
1
1
1
Supplier
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Immunogen 15 amino acid peptide near the carboxy terminus of human TCTN2
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name Tectonic-2 (TCTN2 Antibody Abstract)
Background TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49 % similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.Synonyms: C12orf38, TCTN2, TECT2
Gene ID 79867
NCBI Accession NP_001137322
UniProt Q96GX1
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Tectonic Family Member 2 (TCTN2) (C-Term) antibody (ABIN783638) Western blot analysis of TCTN2 in SK-N-SH cell lysate with TCTN2 antibody at 1 μg/ml.
Background publications Reiter, Skarnes: "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition." in: Genes & development, Vol. 20, Issue 1, pp. 22-7, 2006 (PubMed).