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Details for Product No. ABIN783638

Tectonic Family Member 2 (TCTN2) (C-Term) antibody

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Antigen
Synonyms Tect2, 4432405B04Rik, C12orf38, MKS8, TECT2, fb44f11, wu:fb44f11, tect2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN783638
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Immunogen 15 amino acid peptide near the carboxy terminus of human TCTN2
Purification Affinity chromatography purified via peptide column
Alternative Name Tectonic-2
Background TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Alternate names: C12orf38, TCTN2, TECT2
Gene ID 79867
NCBI Accession NP_001137322
UniProt Q96GX1
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Reiter, Skarnes: "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition." in: Genes & development, Vol. 20, Issue 1, pp. 22-7, 2006 (PubMed).

Alternatives for antigen "Tectonic Family Member 2 (TCTN2)", type "Antibodies"
Hosts (32), (1)
Reactivities (33), (29), (22)
Applications (17), (16), (13), (10), (6), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (2), (1), (1)
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