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NLR Family, Pyrin Domain Containing 12 (NLRP12) (N-Term) antibody

Details for Product No. ABIN783719, Supplier: Log in to see
Antigen
  • Nalp12
  • NALP12
  • CLR19.3
  • FCAS2
  • PAN6
  • PYPAF7
  • RNO
  • RNO2
Epitope
N-Term
28
16
15
3
3
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
79
49
20
1
Host
Rabbit
76
24
5
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
82
60
26
11
7
7
2
2
1
1
1
Supplier
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Immunogen 18 amino acid peptide near the amino terminus of human NALP12
Specificity This antibody detects NALP2 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Alternative Name NALP12 (NLRP12 Antibody Abstract)
Background NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.Synonyms: LRR and PYD domains-containing protein 12, Monarch-1, NACHT, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide
Gene ID 91662
NCBI Accession NP_150639
UniProt P59046
Research Area Signaling, Apoptosis/Necrosis
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (N-Term) antibody (ABIN783719) Western blot analysis of NALP12 in human brain tissue lysate with NALP12 antibody at ...
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).