APBA2 antibody (Center)

Catalog No. ABIN783771

Product Details anti-APBA2 Antibody

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects APBA2 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human APBA2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for APBA2

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Alternative Name: APBA2 (APBA2 Products)

Synonyms: MGC83599 antibody, D15S1518E antibody, HsT16821 antibody, LIN-10 antibody, MGC:14091 antibody, MINT2 antibody, X11-BETA antibody, X11L antibody, X11-like antibody, XllL antibody, mXllL antibody, Mint2 antibody, amyloid beta precursor protein binding family A member 2 antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 antibody, APBA2 antibody, apba2.L antibody, Apba2 antibody

Background: APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, MINT2, Mint-2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, X11L

Gene ID: 321

NCBI Accession: NP_001123886

UniProt: Q99767

Pathways: Synaptic Vesicle Exocytosis