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CXXC4 antibody (N-Term)

CXXC4 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783773
  • Target See all CXXC4 Antibodies
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Binding Specificity
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    • 1
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This CXXC4 antibody is un-conjugated
    Application
    • 21
    • 16
    • 16
    • 14
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects CXXC4 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide near the amino terminus of human CXXC4
    Top Product
    Discover our top product CXXC4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Alternative Name
    CXXC4 (CXXC4 Products)
    Synonyms
    9330210J02Rik antibody, C030003J12Rik antibody, Idax antibody, IDAX antibody, Xldax antibody, xIdax antibody, CXXC finger 4 antibody, CXXC finger protein 4 antibody, CXXC finger protein 4 S homeolog antibody, Cxxc4 antibody, CXXC4 antibody, cxxc4.S antibody
    Background
    CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
    Gene ID
    80319
    NCBI Accession
    NP_079488
    UniProt
    Q9H2H0
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