SLC39A1 antibody (N-Term)

Catalog No. ABIN783795

Product Details anti-SLC39A1 Antibody

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Zinc transporter ZIP1 / SLC39A1 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human ZIP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SLC39A1

Target: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Alternative Name: Zinc Transporter ZIP1 / SLC39A1 (SLC39A1 Products)

Synonyms: cb629 antibody, DrZIP1 antibody, sb:cb629 antibody, zgc:111852 antibody, frzip1p antibody, zip1 antibody, zirtl antibody, ZIP1 antibody, ZIRTL antibody, Zip1 antibody, Zirtl antibody, solute carrier family 39 (zinc transporter), member 1 antibody, solute carrier family 39 member 1 antibody, solute carrier family 39 member 1 L homeolog antibody, slc39a1 antibody, Slc39a1 antibody, SLC39A1 antibody, slc39a1.L antibody

Background: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.Synonyms: IRT1, Solute carrier family 39 member 1, ZIP-1, ZIP1, ZIRTL, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1

Gene ID: 27173

NCBI Accession: NP_055252

UniProt: Q9NY26

Pathways: Autophagy