SLC39A6 antibody (Center)

Catalog No. ABIN783805

Product Details anti-SLC39A6 Antibody

Target: SLC39A6 (Solute Carrier Family 39 (Zinc Transporter), Member 6 (SLC39A6))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC39A6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Zinc transporter ZIP6 / SLC39A6 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human ZIP6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SLC39A6

Target: SLC39A6 (Solute Carrier Family 39 (Zinc Transporter), Member 6 (SLC39A6))

Alternative Name: Zinc Transporter ZIP6 / SLC39A6 (SLC39A6 Products)

Synonyms: liv1 antibody, wu:fc25a09 antibody, ZIP6 antibody, Ermelin antibody, LIV-1 antibody, solute carrier family 39 (zinc transporter), member 6 antibody, solute carrier family 39 member 6 antibody, solute carrier family 39 (metal ion transporter), member 6 antibody, slc39a6 antibody, SLC39A6 antibody, Slc39a6 antibody

Background: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line, down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.Synonyms: Estrogen-regulated protein LIV-1, LIV-1, LIV1, Solute carrier family 39 member 6, ZIP-6, ZIP6, Zrt- and Irt-like protein 6

Gene ID: 25800

NCBI Accession: NP_001092876

UniProt: Q13433

Pathways: Transition Metal Ion Homeostasis