NMNAT3 antibody (Internal Region)

Catalog No. ABIN784277

Product Details anti-NMNAT3 Antibody

Target: NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3))

Binding Specificity: Internal Region

Reactivity: Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This NMNAT3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-KALGQGQSVK YLLPE

Specificity: This antibody is expected to recognize both reported isoforms (NP_835471.1, NP_001186976.1).

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_653116.1. Genename: Nmnat3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NMNAT3

Target: NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3))

Alternative Name: NMNAT3 (NMNAT3 Products)

Synonyms: PNAT-3 antibody, PNAT3 antibody, 4933408N02Rik antibody, nicotinamide nucleotide adenylyltransferase 3 antibody, si:ch73-170l17.1 antibody, Nmnat3 antibody, NMNAT3 antibody, si:ch73-170l17.1 antibody

Background: NMNAT3 belongs to the eukaryotic NMN adenylyltransferase family. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury. Expressed in lung and spleen with lower levels in placenta and kidney.Synonyms: NMN adenylyltransferase 3, Nicotinamide mononucleotide adenylyltransferase 3

Gene ID: 74080

NCBI Accession: NP_653116