IDH3B antibody (C-Term)

Catalog No. ABIN784283

Product Details anti-IDH3B Antibody

Target: IDH3B (Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))

Binding Specificity: AA 369-383, C-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This IDH3B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-TTDFIKSVIG HLQTK

Specificity: This antibody is expected to recognize isoform a (NP_008830.2) and isoform c (NP_777281.1).

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Pig, Cow.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_008830.2, NP_777281.1. Genename: IDH3B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IDH3B

Target: IDH3B (Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B))

Alternative Name: Isocitric Dehydrogenase beta / IDH3B (IDH3B Products)

Synonyms: H-IDHB antibody, RP46 antibody, C78231 antibody, zgc:86647 antibody, MGC79028 antibody, IDH1 antibody, IDH3 antibody, isocitrate dehydrogenase 3 (NAD(+)) beta antibody, isocitrate dehydrogenase 3 (NAD+) beta antibody, isocitrate dehydrogenase 3 (NAD+) beta S homeolog antibody, IDH3B antibody, Idh3B antibody, Idh3b antibody, idh3b antibody, idh3b.S antibody

Background: Defects in IDH3B are the cause of retinitis pigmentosa type 46 (RP46) [MIM:612572]. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the isocitrate and isopropylmalate dehydrogenases family.Synonyms: NAD(+)-specific ICDH beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta

Gene ID: 3420

NCBI Accession: NP_008830