DAPP1 antibody (Internal Region)

Catalog No. ABIN784511

Product Details anti-DAPP1 Antibody

Target: DAPP1 (Dual Adaptor of Phosphotyrosine and 3-phosphoinositides (DAPP1))

Binding Specificity: Internal Region

Reactivity: Human, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This DAPP1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes DAPP1.

Cross-Reactivity (Details): Species reactivity (expected):Canine and Bovine.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: Peptide with sequence C-KLSQIRKQLNQGE, from the internal region (near C Terminus) of the protein sequence according to NP_055210.2.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DAPP1

Target: DAPP1 (Dual Adaptor of Phosphotyrosine and 3-phosphoinositides (DAPP1))

Alternative Name: DAPP1 (DAPP1 Products)

Synonyms: BAM32 antibody, DAPP1 antibody, zgc:111998 antibody, bam32 antibody, Bam32 antibody, dual adaptor of phosphotyrosine and 3-phosphoinositides 1 antibody, dual adaptor of phosphotyrosine and 3-phosphoinositides antibody, dual adaptor for phosphotyrosine and 3-phosphoinositides 1 antibody, DAPP1 antibody, Dapp1 antibody, dapp1 antibody

Background: B cell adapter molecule (BAM32) is also designated a dual adapter for phosphotyrosine and 3-phosphotyrosine, and 3-phosphoinositide (DAPP1) or B lymphocyte adapter protein. BAM32 is a B cell-associated adapter that is crucial for B cell antigen receptor signaling regulation. BAM32 interacts with Ptdlns and PLC γ2 and, upon B cell activation, the protein is phosphorylated on tyrosine residues. It is a mainly cytoplasmic protein that can translocate to the cell membrane after cell stimulation. BAM32, which contains one PH domain and one SH2 domain, is primarily expressed in placenta and lung tissues, but can also be detected in heart, liver, pancreas and brain.Synonyms: BAM32, DKFZp667E0716, Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide, HSPC066, hDAPP1

Gene ID: 27071

NCBI Accession: NP_055210

Pathways: BCR Signaling