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TARDBP antibody (C-Term, Cleavage Site)

TARDBP Reactivity: Human, Rat WB, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN784609
  • Target See all TARDBP Antibodies
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Binding Specificity
    • 15
    • 12
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term, Cleavage Site
    Reactivity
    • 100
    • 59
    • 58
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 102
    • 14
    • 1
    Rabbit
    Clonality
    • 93
    • 24
    Polyclonal
    Conjugate
    • 64
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TARDBP antibody is un-conjugated
    Application
    • 85
    • 47
    • 34
    • 32
    • 21
    • 18
    • 14
    • 13
    • 13
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Specific for the ~ 43 kDa TDP-43 protein in Western blots of Rat brain lysate. Expected molecular weight is dependent upon the TDP-43 species present in sample (full-length vs. truncated TDP-43). Under non-denaturing conditions (for example, by IHC), this antibody detects TDP-43 inclusions in Human brain tissue with TDP-43 proteinopathy, but does not detect full-length nuclear TDP-43. Under denaturing conditions (for example, by Western Blot analysis) this antibody detects the C-terminus of full-length and truncated Human TDP-43.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human and Rat.
    Purification
    Affinity Chromatography.
    Immunogen
    Synthetic peptide C-terminal to the caspase-cleavage site (between D219 and V220) of Human TDP-43.
    Isotype
    IgG
    Top Product
    Discover our top product TARDBP Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 30 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -80 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at -80 °C.
  • Target
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Alternative Name
    TARDBP (TARDBP Products)
    Synonyms
    TARDBP antibody, TDP43 antibody, DKFZp459I2127 antibody, tardbp antibody, ALS10 antibody, TDP-43 antibody, 1190002A23Rik antibody, C85084 antibody, Tdp43 antibody, wu:fb77f02 antibody, wu:fc52g10 antibody, TAR DNA binding protein antibody, Tardbp protein antibody, TAR DNA binding protein L homeolog antibody, TAR DNA-binding protein 43-like antibody, TARDBP antibody, tardbp antibody, tardbp.L antibody, Tardbp antibody, LOC100621383 antibody
    Background
    TDP43 (Tar DNA Binding 43, TARDBP) was originally identified as a protein which binds to the "transactivation response" (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome (Ou et al.,1995). UV cross-linking of HeLa cell extract revealed a 43 kDa protein which was cloned and sequenced and shown to contain two copies of the ~90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (Neumann et al., 2006). The protein is present in these inclusions in partially degraded, hyperphosphorylated and ubiquitinated forms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
    Gene ID
    23435
    NCBI Accession
    NP_031401
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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