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PRDM16 antibody (Middle Region)

PRDM16 Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN784762
  • Target See all PRDM16 Antibodies
    PRDM16 (PR Domain Containing 16 (PRDM16))
    Binding Specificity
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Pig
    Host
    • 15
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 17
    • 2
    Polyclonal
    Conjugate
    • 15
    • 2
    • 1
    • 1
    This PRDM16 antibody is un-conjugated
    Application
    • 13
    • 10
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    LNHTQDAKLP SPLGNPALPL VSAVSNSSQG TTAAAGPEEK FESRLEDSCV
    Predicted Reactivity
    Cow: 92%, Dog: 77%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 92%, Rat: 86%
    Characteristics
    This is a rabbit polyclonal antibody against PRDM16. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PRDM16
    Top Product
    Discover our top product PRDM16 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1275 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PRDM16 (PR Domain Containing 16 (PRDM16))
    Alternative Name
    PRDM16 (PRDM16 Products)
    Synonyms
    PRDM16 antibody, wu:fc09g08 antibody, MEL1 antibody, PFM13 antibody, 5730557K01Rik antibody, C130091E20 antibody, csp1 antibody, mKIAA1675 antibody, mel1 antibody, PR/SET domain 16 antibody, PR domain containing 16 antibody, PRDM16 antibody, prdm16 antibody, Prdm16 antibody
    Background
    The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
    Alias Symbols: KIAA1675, MEL1, PFM13
    Protein Interaction Partner: TFAP4, UBC, HDAC2, Ctbp2, SUMO1, SKI, SMAD3, SMAD2, INADL,
    Protein Size: 1275
    Molecular Weight
    140 kDa
    Gene ID
    63976
    NCBI Accession
    NM_022114, NP_071397
    UniProt
    Q9HAZ2
    Pathways
    Stem Cell Maintenance, Brown Fat Cell Differentiation
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