nectin-3 antibody (Middle Region)

Catalog No. ABIN785184

Product Details anti-nectin-3 Antibody

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This nectin-3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PDSVKKENKN PVNNLIRKDY LEEPEKTQWN NVENLNRFER PMDYYEDLKM

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PVRL3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PVRL3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 549 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for nectin-3

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Alternative Name: PVRL3 (NECTIN3 Products)

Synonyms: PVRL3 antibody, CD113 antibody, CDW113 antibody, NECTIN-3 antibody, PPR3 antibody, PRR3 antibody, PVRR3 antibody, 2610301B19Rik antibody, 3000002N23Rik antibody, 4921513D19Rik antibody, AA407785 antibody, AU016832 antibody, AW538082 antibody, nectin cell adhesion molecule 3 antibody, poliovirus receptor-related 3 antibody, Nectin3 antibody, NECTIN3 antibody, PVRL3 antibody, nectin3 antibody

Background: Nectins (e.g., PVRL1, MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.
Alias Symbols: CDw113, DKFZP566B0846, FLJ90624, PPR3, PRR3, PVRR3, nectin-3, CD113, CDW113, NECTIN-3
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-9, KRTAP10-7, KRTAP4-2, RGS20, UBC, BAG3, TIGIT, PVRL2, PVRL1, PARD3, PVR, MLLT4, PVRL3,
Protein Size: 549

Molecular Weight: 61 kDa

Gene ID: 25945

NCBI Accession: NM_015480, NP_056295

UniProt: Q9NQS3

Pathways: Cell-Cell Junction Organization