H1FOO antibody (Middle Region)

Catalog No. ABIN785647

Product Details anti-H1FOO Antibody

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H1FOO antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KAPKAGQGPN TKAAAPAKGS GSKVVPAHLS RKTEAPKGPR KAGLPIKASS

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against H1FOO. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human H1FOO

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 346 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for H1FOO

Target: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Alternative Name: H1FOO (H1FOO Products)

Synonyms: osH1 antibody, C86609 antibody, H1fo antibody, H1oo antibody, b4 antibody, RGD1566236 antibody, H1 histone family member O oocyte specific antibody, H1 histone family, member O, oocyte-specific antibody, H1 histone family member O oocyte specific S homeolog antibody, H1FOO antibody, H1foo antibody, h1foo.S antibody

Background: H1FOO may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. H1FOO is essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.
Alias Symbols: MGC50807, osH1
Protein Size: 346

Molecular Weight: 36 kDa

Gene ID: 132243

NCBI Accession: NM_153833, NP_722575

UniProt: Q8IZA3