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Integrin beta 3 antibody (ITGB3) (FITC)

Details for Product anti-ITGB3 Antibody No. ABIN810079, Supplier: Log in to see
Antigen
  • BDPLT2
  • BDPLT16
  • CD61
  • GP3A
  • GPIIIA
  • GPIIIa
  • GT
  • INGRB3
  • INTB3
  • integrin
Reactivity
Human, Non-Human Primate
526
217
180
20
19
16
15
11
8
4
4
4
3
3
3
2
2
1
1
1
1
Host
Mouse
327
222
59
29
12
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is conjugated to FITC
82
55
26
16
12
10
10
8
7
7
7
6
5
5
5
5
5
4
4
4
4
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
383
265
145
108
78
77
75
49
31
25
23
12
7
6
5
5
4
4
2
2
2
2
1
1
1
Supplier
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Clone VIPL2
Isotype IgG1
Specificity The mouse monoclonal antibody VIPL2 recognizes CD61, a 90-110 kDa transmembrane glycoprotein of integrin family, expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leucocytes and smooth muscle cells.
HLDA V., WS Code 5T-124
Characteristics The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Alternative Name ITGB3 (ITGB3 Antibody Abstract)
Background CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 Molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
Gene ID 3690
Research Area Surface Receptors of Immune Cells, CD Antigens
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests.
Restrictions For Research Use only
Reconstitution No reconstitution is necessary.
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Product cited in: Barrett, Dai, Gamberg, Gallant, Grant: "Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10." in: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 152-60, 2007 (PubMed).

Mondal, Williams, Ali, Eilers, Agrawal: "The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 9, pp. 631-44, 2005 (PubMed).

Williams, Mondal, Agrawal: "The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 11, pp. 872-84, 2005 (PubMed).

Roberts, Woods, Dale, Van Der Sluijs, Norman: "Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1505-15, 2004 (PubMed).

Ciarlet, Crawford, Cheng, Blutt, Rice, Bergelson, Estes: "VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment." in: Journal of virology, Vol. 76, Issue 3, pp. 1109-23, 2002 (PubMed).

Dzionek, Fuchs, Schmidt, Cremer, Zysk, Miltenyi, Buck, Schmitz: "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6037-46, 2000 (PubMed).