Ptges3l antibody
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- Target See all Ptges3l (PTGES3L) products
- Ptges3l (PTGES3L) (Prostaglandin E Synthase 3 (Cytosolic)-Like (PTGES3L))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Ptges3l antibody is un-conjugated
- Application
- Western Blotting (WB), Immunohistochemistry (IHC), Antibody Array (AA)
- Specificity
- Detects ~19 kDa. Detects Tsp23, no cross-reactivity to p23.
- Cross-Reactivity
- Human, Mouse
- Purification
- Protein G Purified
- Immunogen
- Recombinant tsp23
- Clone
- Tsp232A
- Isotype
- IgG1 kappa
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- Application Notes
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- WB (1:1000)
- IHC (1:1000)
- optimal dilutions for assays should be determined by the user.
- Comment
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1 μg/ml of ABIN863111 was sufficient for detection of tsp23 in 20 μg of transiently transfected Hela cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- Ptges3l (PTGES3L) (Prostaglandin E Synthase 3 (Cytosolic)-Like (PTGES3L))
- Alternative Name
- TSP23 (PTGES3L Products)
- Synonyms
- 1110069E20Rik antibody, 1700113I22Rik antibody, prostaglandin E synthase 3 like antibody, Ptges3l antibody, PTGES3L antibody
- Background
- P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology. Specifically TSP23 (transcript similar p23) displays 44 % and 17 % amino acid identity with p23 and Sba1p respectively (10).
- Gene ID
- 80755
- NCBI Accession
- NP_001136126
- UniProt
- B9A003
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