Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) (AA 458-476), (C-Term) antibody

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Antigen
Epitope
AA 458-476, C-Term
(43), (37), (36), (35), (26), (17), (17), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(113), (111), (79), (4), (1), (1)
Host
Mouse
(87), (85)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (10), (8), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(157), (87), (70), (54), (50), (40), (10), (10), (4), (4), (3), (2), (1)
Pubmed 4 references available
Quantity 100 μg
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Immunogen Synthetic peptide amino acids 458-476 (cytoplasmic C-terminus) of rat Kv1.1 (EEDMNNSIAHYRQANIRTG)
Clone S20-78
Specificity Detects ~85 kDa (major: Mature glycosylation), ~65 kDa (minor: immature glycosylation).
Sensitivity 1 µg/mL of SMC-355 was sufficient for detection of Kv1.1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name Kv1.1 (KCNA1 Antibody Abstract)
Background Kv1.1, also known as potassium voltage-gated channel subfamily A member 1, is a shaker related voltage potassium channel that in humans is encoded by the SCNA1 gene (1-3). It is strongly expressed in a variety of neurons in adult rodents, and it appears to be involved in regulating neuronal excitability. Specifically it plays a role in several developmental processes including proliferation, migration and cell-cell adhesion (4). The Isaacs syndrome is a result of an autoimmune reaction against the Kv1.1 ion channel (5).
Cellular Localization: Membrane
Gene ID 24520
NCBI Accession NP_775118
UniProt P10499
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) (AA 458-476), (C-Term) antibody Kv1.
Background publications Gutman, Chandy, Grissmer et al.: "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 473-508, 2005 (PubMed).

Hallows, Tempel: "Expression of Kv1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 15, pp. 5682-91, 1998 (PubMed).

Newsom-Davis: "Autoimmune neuromyotonia (Isaacs' syndrome): an antibody-mediated potassium channelopathy." in: Annals of the New York Academy of Sciences, Vol. 835, pp. 111-9, 1998 (PubMed).

Albrecht, Weber, Pongs: "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13." in: Receptors & channels, Vol. 3, Issue 3, pp. 213-20, 1996 (PubMed).

Validation Images
Catalog No. ABIN863148
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