SH3-Domain GRB2-Like 1 (SH3GL1) (AA 287-302) antibody

Details for Product No. ABIN863156
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Antigen
Synonyms cb831, sh3gl1, MGC78966, MGC130739, CNSA1, EEN, SH3D2B, SH3P8, C77078, Sh3d2b
Epitope
AA 287-302
(18), (8), (7), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(33), (21), (4), (2), (1), (1)
Host
Mouse
(33), (17), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(52), (25), (25), (20), (15), (5), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN863156
367.40 $
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Immunogen Synthetic peptide AA 287-302 od rat SH3GL1
Clone S51-1
Isotype IgG1
Specificity Approx. 43 kDa.
Sensitivity 1 µg/mL of SMC-363 was sufficient for detection of SH3GL1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name SH3GL1
Background Synonyms:
SH3 domain GRB2 like 1 protein, CNSA1, SH3P8, EEN
Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene. Endophilin-A2 is an SH3 domain containing protein that is involved in the clathrin-mediated endocytosis and recycling of synaptic vesicles. Its SH3domain lies at the C-terminus of the protein, and can bind proline-rich sequences on other endocytotic proteins. It also binds the C-terminus of the voltage-gated calcium channel in a calcium-dependent manner, which serves to enrich the endocytotic machinery at nerve terminals.
Gene ID 6455
NCBI Accession NP_003016
UniProt Q99961
Research Area Scaffolds
Application Notes Recommended Dilution: 1 µg/mL (WB), 0.1-1 µg/mL (IHC/ICC), 1-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Ringstad, Nemoto, De Camilli: "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8569-74, 1997 (PubMed).

Chen, Deng, Maeno-Hikichi et al.: "Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis." in: Cell, Vol. 115, Issue 1, pp. 37-48, 2003 (PubMed).

Loll, Swain, Chen et al.: "Structure of the SH3 domain of rat endophilin A2." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 64, Issue Pt 4, pp. 243-6, 2008 (PubMed).

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