Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A) (AA 2680-2749), (C-Term) antibody

Details for Product No. ABIN863181
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AA 2680-2749, C-Term
(17), (17), (17), (12), (1)
Human, Mouse (Murine), Rat (Rattus)
(31), (29), (29)
(17), (14)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(18), (18), (18), (10), (3), (1), (1)
Pubmed 5 references available
Quantity 100 μg
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Immunogen Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1
Clone S24-18
Specificity Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R's.
Sensitivity 1 µg/mL of SMC-388 was sufficient for detection of IP3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name IP3 Receptor (ITP-R83A Antibody Abstract)
Background Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation (1). Four individual receptor subunits, resulting in homo- or hetero-oligomerization of the receptor isoform, form a functional channel (2). Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release (3, 4). IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells (5).
Cellular Localization: Endoplasmic reticulum membrane
Gene ID 25262
NCBI Accession NP_001007236
UniProt P29994
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A) (AA 2680-2749), (C-Term) antibody (ABIN863181) IP3 receptor rat brain membranes 20ug Western Blotting 1 in 1000 copy.
Background publications DeSouza, Reiken, Ondrias et al.: "Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39397-400, 2002 (PubMed).

Galvan, Borrego-Diaz, Perez et al.: "Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor." in: The Journal of biological chemistry, Vol. 274, Issue 41, pp. 29483-92, 1999 (PubMed).

Haug, Jensen, Hvalby et al.: "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7467-73, 1999 (PubMed).

Inoue, Kato, Kohda et al.: "Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 14, pp. 5366-73, 1998 (PubMed).

Joseph: "The inositol triphosphate receptor family." in: Cellular signalling, Vol. 8, Issue 1, pp. 1-7, 1996 (PubMed).

Validation Images
Catalog No. ABIN863181
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