Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A) (C-Term), (AA 2680-2749) antibody

Details for Product No. ABIN863181
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Antigen
Epitope
C-Term, AA 2680-2749
Reactivity
Human, Rat (Rattus)
(13), (12), (12), (12), (12), (12)
Host
Mouse
(13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(10), (3), (3), (1), (1)
Pubmed 4 references available
Catalog no. ABIN863181
Quantity 100 µg
Price
367.40 $   Plus shipping costs $45.00
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Immunogen Fusion protein AA 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1 Itpr1
Clone S24-18
Isotype IgG1
Specificity Detects approx. 300 kDa. Does not recognize type 2 or type 3 IP3R's.
Sensitivity 1 µg/mL of SMC-388 was sufficient for detection of IP3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name IP3 Receptor
Background Synonyms:
IP3 Receptor, S24-18
Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium releasechannel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual receptor subunits, resulting in homo- or hetero-oligomerization of the receptor isoform, form a functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic-AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release. IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells.
Gene ID 25262
NCBI Accession NP_001007236.1
UniProt P29994
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: 1 µg/mL (WB), 0.1-1 µg/mL (IHC/ICC), 1-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A) (C-Term), (AA 2680-2749) antibody IP3 receptor rat brain membranes 20ug Western Blotting 1 in 1000 copy.
Background publications Inoue, Kato, Kohda et al.: "Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 14, pp. 5366-73, 1998 (PubMed).

Haug, Jensen, Hvalby et al.: "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7467-73, 1999 (PubMed).

Galvan, Borrego-Diaz, Perez et al.: "Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor." in: The Journal of biological chemistry, Vol. 274, Issue 41, pp. 29483-92, 1999 (PubMed).

DeSouza, Reiken, Ondrias et al.: "Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39397-400, 2002 (PubMed).

Hosts (13)
Reactivities (13), (12), (12), (12), (12), (12)
Applications (10), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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