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tau antibody (pSer416)

Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN871413
  • Target See all tau Antibodies
    tau (tau Protein)
    Binding Specificity
    • 31
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    • 30
    • 26
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    • 26
    • 24
    • 23
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pSer416
    Reactivity
    • 525
    • 500
    • 499
    • 40
    • 28
    • 27
    • 18
    • 6
    • 3
    • 2
    • 1
    • 1
    Rat
    Host
    • 630
    • 35
    • 2
    • 1
    Rabbit
    Clonality
    • 605
    • 62
    • 1
    Polyclonal
    Conjugate
    • 208
    • 40
    • 34
    • 33
    • 33
    • 33
    • 32
    • 32
    • 32
    • 30
    • 24
    • 24
    • 24
    • 24
    • 24
    • 13
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    This tau antibody is un-conjugated
    Application
    • 548
    • 272
    • 263
    • 205
    • 92
    • 85
    • 67
    • 59
    • 53
    • 36
    • 34
    • 16
    • 12
    • 12
    • 12
    • 9
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    The antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
    Purification
    Affinity purified
    Immunogen
    Peptide sequence around phosphorylation site of pSer416 (T-G-S (p) -I-D) derived from Rat Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Top Product
    Discover our top product tau Primary Antibody
  • Application Notes
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    tau (tau Protein)
    Alternative Name
    Tau (tau Products)
    Synonyms
    DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, tau antibody, PHF-tau antibody, microtubule associated protein tau antibody, MAPT antibody
    Background
    Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies
    Molecular Weight
    78 kDa
    Gene ID
    29477
    NCBI Accession
    NP_058908
    UniProt
    P19332
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