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CD22 antibody (AA 839-843)

CD22 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

Catalog No. ABIN871517

Datasheet as PDF

Target See all CD22 Antibodies

CD22 (CD22 Molecule (CD22))
Binding Specificity
16

11

6

5

4

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 839-843
Reactivity
150

48

24

5

3

2

2

1
Human
Host
97

62

13
Rabbit
Compatible Secondaries
Clonality
120

54
Polyclonal
Conjugate
81

14

12

10

6

5

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This CD22 antibody is un-conjugated
Application
109

69

45

38

37

17

12

11

11

6

5

4

3

3

3

1

1

1

1

1
Western Blotting (WB)

Specificity

The antibody detects endogenous level of total CD22 protein.

Purification

Affinity purified

Immunogen

Peptide sequence around AA 839-843 (N-V-D-Y-V) derived from Human CD22. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

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CD22 Reactivity: Human FACS Host: Mouse Monoclonal IS7 FITC

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CD22 Reactivity: Human, Mouse, Rat, Monkey, Dog WB, IHC, IHC (p) Host: Mouse Monoclonal 4C3 unconjugated

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CD22 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated

anti-CD22 Molecule (CD22) (AA 52-178) antibody
CD22 Reactivity: Human IHC Host: Rabbit Monoclonal MSVA-022R unconjugated Recombinant Antibody

Application Notes

Western blotting: 1:500-1:1000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C/-20 °C

Storage Comment

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target

CD22 (CD22 Molecule (CD22))

Alternative Name

CD22 (CD22 Products)

Synonyms

A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody

Background

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Molecular Weight

140 kDa

Gene ID

933

NCBI Accession

NP_001762

UniProt

P20273