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Tafazzin (TAZ) (AA 386-390) antibody

Details for Product No. ABIN871563, Supplier: Log in to see
Antigen
Epitope
AA 386-390
20
18
13
11
11
5
5
5
5
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
121
32
32
3
2
1
1
Host
Rabbit
97
19
15
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
6
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Western Blotting (WB)
90
62
22
15
8
7
5
4
4
3
2
1
1
Supplier
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Immunogen Peptide sequence around AA 386-390 (V-E-S-A-L) derived from Human TAZ. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total TAZ protein.
Purification Affinity purified
Alternative Name TAZ (TAZ Antibody Abstract)
Background Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Molecular Weight 49 kDa
Gene ID 25937
NCBI Accession NP_001161
UniProt Q9GZV5
Research Area Stem Cells, Transcription Factors
Pathways
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Di Palma, DAndrea, Liguori et al.: "TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation." in: Experimental cell research, Vol. 315, Issue 2, pp. 162-75, 2008 (PubMed).

Varelas, Sakuma, Samavarchi-Tehrani et al.: "TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal." in: Nature cell biology, Vol. 10, Issue 7, pp. 837-48, 2008 (PubMed).

Lei, Zhang, Zhao et al.: "TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2426-36, 2008 (PubMed).

Kanai, Marignani, Sarbassova et al.: "TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins." in: The EMBO journal, Vol. 19, Issue 24, pp. 6778-91, 2001 (PubMed).

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