TFE3 antibody (AA 303-307)

Catalog No. ABIN871655

Product Details anti-TFE3 Antibody

Target: TFE3 (Transcription Factor E3 (TFE3))

Binding Specificity: AA 303-307

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFE3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous levels of total TFE3 protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 303-307 (L-D-V-Y-S) derived from Human TFE3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Alternative Name: TFE3 (TFE3 Products)

Synonyms: RCCP2 antibody, RCCX1 antibody, TFEA antibody, bHLHe33 antibody, F830016E06Rik antibody, Tcfe3 antibody, Tfe-3 antibody, RGD1559642 antibody, cb873 antibody, zgc:109815 antibody, transcription factor binding to IGHM enhancer 3 antibody, transcription factor E3 antibody, transcription factor binding to IGHM enhancer 3 S homeolog antibody, transcription factor binding to IGHM enhancer 3a antibody, TFE3 antibody, Tfe3 antibody, tfe3.S antibody, tfe3a antibody

Background: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

Molecular Weight: 70 kDa

Gene ID: 7030

NCBI Accession: NP_006512

UniProt: P19532