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MAP2K5 antibody (Mitogen-Activated Protein Kinase Kinase 5) (AA 311-315)

Details for Product anti-MAP2K5 Antibody No. ABIN871696, Supplier: Log in to see
Antigen
  • Mek5
  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5
  • AI324775
  • AI428457
  • Mapkk5
  • Prkmk5
  • fb73f02
  • wu:fb73f02
  • zgc:172137
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAP2K_A
Alternatives
anti-Human MAP2K5 antibody for Western Blotting
Epitope
AA 311-315
30
29
17
17
15
13
13
13
13
6
5
5
4
4
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
147
71
71
9
7
7
6
5
3
2
2
1
1
1
1
Host
Rabbit
147
16
Clonality
Polyclonal
Conjugate
This MAP2K5 antibody is un-conjugated
9
9
9
5
5
5
5
5
5
5
5
4
4
4
4
Application
Western Blotting (WB)
103
54
47
24
19
18
4
2
1
1
Supplier
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Immunogen Peptide sequence around AA 311-315 (K-T-Y-V-G ) derived from Rat MEK5. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total MEK5 protein.
Purification Affinity purified
Alternative Name MEK5 (MAP2K5 Antibody Abstract)
Background A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
Molecular Weight 49 kDa
Gene ID 29568
NCBI Accession NP_001029
UniProt Q62862
Research Area Cancer, Kinases/Phosphatases
Pathways MAPK Signaling, Neurotrophin Signaling Pathway
Application Notes Western blotting: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Holland, Suzanne, Campbell et al.: "MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 24994-8, 1997 (PubMed).

Tournier, Whitmarsh, Cavanagh et al.: "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 14, pp. 7337-42, 1997 (PubMed).

Jiang, Chen, Li et al.: "Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17920-6, 1996 (PubMed).

Han, Lee, Jiang et al.: "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)." in: The Journal of biological chemistry, Vol. 271, Issue 6, pp. 2886-91, 1996 (PubMed).