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RING1 antibody (AA 35-39)

RING1 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN871729
  • Target See all RING1 Antibodies
    RING1 (Ring Finger Protein 1 (RING1))
    Binding Specificity
    • 9
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 35-39
    Reactivity
    • 63
    • 19
    • 18
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    Human, Mouse, Rat
    Host
    • 46
    • 19
    Rabbit
    Clonality
    • 47
    • 18
    Polyclonal
    Conjugate
    • 38
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RING1 antibody is un-conjugated
    Application
    • 47
    • 28
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    The antibody detects endogenous level of total Ring1A protein.
    Purification
    Affinity purified
    Immunogen
    Peptide sequence around AA 35-39 ( I-A-V-S-P) derived from Human Ring1A. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product RING1 Primary Antibody
  • Application Notes
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    RING1 (Ring Finger Protein 1 (RING1))
    Alternative Name
    Ring1A (RING1 Products)
    Synonyms
    RING1A antibody, RNF1 antibody, Ring1A antibody, bap-1 antibody, bap1 antibody, ding antibody, hipi3 antibody, ring1a antibody, ring1b antibody, ring2 antibody, rnf1 antibody, rnf2-a antibody, ring1 antibody, ring1b-B antibody, rnf2-b antibody, ring finger protein 1 antibody, ring finger protein 1 S homeolog antibody, ring finger protein 1 L homeolog antibody, RING1 antibody, Ring1 antibody, ring1.S antibody, ring1.L antibody
    Background
    Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
    Molecular Weight
    58 kDa
    Gene ID
    6015
    NCBI Accession
    NP_002922
    UniProt
    Q06587
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