Doublecortin antibody (AA 413-417)

Catalog No. ABIN871730

Product Details anti-Doublecortin Antibody

Target: Doublecortin (DCX)

Binding Specificity: AA 413-417

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Doublecortin antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous level of total Doublecortin protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 413-417 ( P-T-S-P-G) derived from Human Doublecortin. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Doublecortin

Target: Doublecortin (DCX)

Alternative Name: Doublecortin (DCX Products)

Synonyms: DCX antibody, DBCN antibody, DC antibody, LISX antibody, SCLH antibody, XLIS antibody, Dbct antibody, 18C15.5 antibody, doublecortin antibody, DCX antibody, Dcx antibody

Background: Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.

Molecular Weight: 40-45 kDa

Gene ID: 1641

NCBI Accession: NP_000546

UniProt: O43602