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KIT Ligand antibody (AA 265-269)

KITLG Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN871770
  • Target See all KIT Ligand (KITLG) Antibodies
    KIT Ligand (KITLG)
    Binding Specificity
    • 16
    • 11
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 265-269
    Reactivity
    • 105
    • 48
    • 36
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 105
    • 22
    • 9
    • 1
    Rabbit
    Clonality
    • 105
    • 31
    Polyclonal
    Conjugate
    • 73
    • 19
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KIT Ligand antibody is un-conjugated
    Application
    • 112
    • 57
    • 45
    • 29
    • 25
    • 17
    • 16
    • 15
    • 14
    • 13
    • 10
    • 6
    • 6
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    The antibody detects endogenous level of total SCF protein.
    Purification
    Affinity purified
    Immunogen
    Peptide sequence around AA 265-269 (E-K-E-R-E) derived from Human SCF. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product KITLG Primary Antibody
  • Application Notes
    Western blotting: 1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    KIT Ligand (KITLG)
    Alternative Name
    SCF (KITLG Products)
    Synonyms
    Xkl-1 antibody, Xsl antibody, Xsl-1 antibody, Xsl-2 antibody, steel antibody, KITLG antibody, SCF antibody, kitl antibody, kl-1 antibody, mgf antibody, scf antibody, FPH2 antibody, KL-1 antibody, Kitl antibody, MGF antibody, SF antibody, SHEP7 antibody, Clo antibody, Con antibody, Gb antibody, Kitlg antibody, Mgf antibody, SLF antibody, Sl antibody, blz antibody, contrasted antibody, 710-712 antibody, CSF antibody, KITL antibody, KIT ligand L homeolog antibody, KIT ligand antibody, kit ligand antibody, kitlg.L antibody, KITLG antibody, kitlg antibody, Kitl antibody, Kitlg antibody
    Background
    Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
    Molecular Weight
    25-38 kDa
    Gene ID
    4254
    NCBI Accession
    NP_000890
    UniProt
    P21583
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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