TBCD antibody (AA 401-500)

Catalog No. ABIN872398

Product Details anti-TBCD Antibody

Target: TBCD (Tubulin Folding Cofactor D (TBCD))

Binding Specificity: AA 401-500

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBCD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TBCD/Beta tubulin cofactor D

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TBCD

Target: TBCD (Tubulin Folding Cofactor D (TBCD))

Alternative Name: Beta tubulin cofactor D (TBCD Products)

Background:

Synonyms: Beta tubulin cofactor D, Beta-tubulin cofactor D, KIAA0988, SSD 1, SSD-1, SSD1, tbcd, TBCD_HUMAN, tfcD, Tubulin folding cofactor D, Tubulin specic chaperone D, Tubulin-folding cofactor D, Tubulin-specic chaperone D.

Background: Tubulin-folding protein, involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.

Gene ID: 6904

Pathways: Cell-Cell Junction Organization