PLEKHF1 antibody (AA 75-124)

Catalog No. ABIN872648

Product Details anti-PLEKHF1 Antibody

Target: PLEKHF1 (Pleckstrin Homology Domain Containing, Family F (With FYVE Domain) Member 1 (PLEKHF1))

Binding Specificity: AA 75-124

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLEKHF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APPD/ Apoptosis-inducing protein

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PLEKHF1

Target: PLEKHF1 (Pleckstrin Homology Domain Containing, Family F (With FYVE Domain) Member 1 (PLEKHF1))

Alternative Name: APPD (PLEKHF1 Products)

Synonyms: zgc:63897 antibody, PLEKHF1 antibody, APPD antibody, LAPF antibody, PHAFIN1 antibody, ZFYVE15 antibody, 1810013P09Rik antibody, pleckstrin homology domain containing, family F (with FYVE domain) member 1 antibody, pleckstrin homology and FYVE domain containing 1 antibody, plekhf1 antibody, PLEKHF1 antibody, Plekhf1 antibody

Background:

Synonyms: APPD, LAPF, PHAFIN1, ZFYVE15, Pleckstrin homology domain-containing family F member 1, PH domain-containing family F member 1, Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains, Apoptosis-inducing protein, PH and FYVE domain-containing protein 1, Phafin-1, Zinc finger FYVE domain-containing protein 15, PLEKHF1

Background: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.

Gene ID: 79156

UniProt: Q96S99