RPS6KA1 antibody (pSer352) (Alexa Fluor 555)

Catalog No. ABIN875692

Product Details anti-RPS6KA1 Antibody (Alexa Fluor 555)

Target: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Binding Specificity: pSer352

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KA1 antibody is conjugated to Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human RPS6KA1 around the phosphorylation site of Ser352

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RPS6KA1

Target: RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Alternative Name: RPS6KA1 (RPS6KA1 Products)

Synonyms: HU-1 antibody, MAPKAPK1A antibody, RSK antibody, RSK1 antibody, Rsk1 antibody, p90rsk antibody, rsk antibody, RPS6KA antibody, hu-1 antibody, mapkapk1a antibody, rsk1 antibody, wu:fc56h07 antibody, zgc:152654 antibody, ribosomal protein S6 kinase A1 antibody, ribosomal protein S6 kinase polypeptide 1 antibody, ribosomal protein S6 kinase A1-like antibody, ribosomal protein S6 kinase A1 L homeolog antibody, ribosomal protein S6 kinase a, polypeptide 1 antibody, RPS6KA1 antibody, Rps6ka1 antibody, RPS6KA1L antibody, rps6ka1.L antibody, rps6ka1 antibody

Background:

Synonyms: p90RSK Ser352, RPS6KA1phospho S352, p90 RSK1 , p90rsk , p90S6K , pp90RSK1 , Ribosomal protein S6 kinase 90kD 1 , Ribosomal protein S6 kinase 90kD polypeptide 1 , Ribosomal protein S6 kinase 90 kDa polypeptide 1 , Ribosomal protein S6 kinase alpha 1 , Ribosomal protein S6 kinase polypeptide 1 , Ribosomal S6 kinase 1 , RPS6K1 alpha , rps6ka , Rps6ka1 , RSK 1 , RSK 1 p90 , RSK , RSK1 , S6K alpha 1 , 90 kDa ribosomal protein S6 kinase 1 , dJ590P13.1 ribosomal protein S6 kinase, 90kD, polypeptide 1 , dJ590P13.1 , EC 2.7.11.1 , HU 1 , HU1 , MAP kinase activated protein kinase 1a , MAPKAP kinase 1A , MAPKAPK1A , MGC79981 , Mitogen-activated protein kinase-activated protein kinase 1A, KS6A1_MOUSE.

Background: Rsk1 is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.

Gene ID: 6195

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades