BTG1, BTG2 (AA 41-140) antibody (Alexa Fluor 647)

Catalog No. ABIN885717

Product Details

Target: BTG1, BTG2

Binding Specificity: AA 41-140

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BTG1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: BTG1, BTG2

Alternative Name: BTG1 and BTG2

Background:

Synonyms: B cell translocation gene 1 protein, B cell translocation gene 1, anti prolerative, BTG1 protein, BTG1_HUMAN, BTG2_HUMAN, Protein BTG2, BTG family member 2, NGF-inducible anti-prolerative protein PC3, pheochromacytoma cell-3, nerve growth factor-inducible anti-prolerative, B-cell translocation gene 2, BTG2, TIS21, PC3, TIS21

Background: BTG1 belongs to the BTG family of proteins.FUNCTION: Anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B cell chronic lymphocytic leukemia, translocation t(8,12)(q24,q22) with MYC. BTG2 is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. BTG2 is involved in the regulation of the G1/S transition of the cell cycle. It modulates transcription regulation mediated by ESR1(referenced from Entrez Gene). BTG2 expression is induced in vivo during neurogenesis, and the gene is transiently expressed in vitro in rat pheochromocytoma PC12 cells after induction of neuronal differentiation by addition of nerve growth factor (NGF), suggesting that BTG2 is functionally significant during the neuronal differentiation process (PMID: 12360398).

Gene ID: 694, 7832

UniProt: P62324, P78543