Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CUBN antibody (AA 51-150) (Alexa Fluor 350)

CUBN Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN892692
  • Target See all CUBN Antibodies
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Binding Specificity
    • 14
    • 7
    • 5
    • 2
    • 1
    AA 51-150
    Reactivity
    • 30
    • 9
    • 7
    Human
    Host
    • 43
    • 1
    Rabbit
    Clonality
    • 35
    • 9
    Polyclonal
    Conjugate
    • 13
    • 10
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CUBN antibody is conjugated to Alexa Fluor 350
    Application
    • 22
    • 16
    • 12
    • 12
    • 8
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Cubilin
    Isotype
    IgG
    Top Product
    Discover our top product CUBN Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Alternative Name
    Cubilin (CUBN Products)
    Synonyms
    GP280 antibody, IFCR antibody, MGA1 antibody, AA408369 antibody, AL022750 antibody, D2Wsu88e antibody, gp280 antibody, cubilin antibody, cubilin (intrinsic factor-cobalamin receptor) antibody, LOC411053 antibody, CUBN antibody, cubn antibody, Cubn antibody
    Background

    Synonyms: IFCR, MGA1, gp280, Cubilin, 460 kDa receptor, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor, CUBN

    Background: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

    Gene ID
    8029
    UniProt
    O60494
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism
You are here:
Support