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DEDD2 antibody (AA 201-300) (Alexa Fluor 350)

DEDD2 Reactivity: Rat IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN893832
  • Target See all DEDD2 Antibodies
    DEDD2 (Death Effector Domain Containing 2 (DEDD2))
    Binding Specificity
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivity
    • 18
    • 16
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Rat
    Host
    • 31
    Rabbit
    Clonality
    • 31
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DEDD2 antibody is conjugated to Alexa Fluor 350
    Application
    • 12
    • 12
    • 8
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DEDD2
    Isotype
    IgG
    Top Product
    Discover our top product DEDD2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    DEDD2 (Death Effector Domain Containing 2 (DEDD2))
    Alternative Name
    DEDD2 (DEDD2 Products)
    Synonyms
    FLAME-3 antibody, MGC145883 antibody, 2410050E11Rik antibody, DEDD2 antibody, death effector domain containing 2 antibody, death effector domain containing 2 L homeolog antibody, death effector domain-containing DNA binding protein 2 antibody, DEDD2 antibody, dedd2.L antibody, dedd2 antibody, Dedd2 antibody
    Background

    Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,

    Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

    Gene ID
    162989
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